Antibacterial activity of polysaccharides from the fruiting bodies of Boletus edulis and Lactarius indigo

Resumen

Objective: This study aimed to evaluate the antibacterial activity of aqueous and alkaline polysaccharide fractions extracted from wild fruiting bodies of Boletus edulis and Lactarius indigo from central Mexico. Design/methodology/approach: Polysaccharides were obtained and separated into aqueous (FAq) and alkaline (FAk) fractions, characterized by Fourier transform infrared spectroscopy (FTIR), and tested at concentrations of 500, 250, 125, and 62.5 μg mL⁻¹ using the broth dilution method against Staphylococcus aureus, Escherichia coli, Enterococcus faecalis, and Streptococcus mutans. Results: Four polysaccharide fractions were obtained (FAqBe, FAkBe, FAqLi, and FAkLi). All fractions exhibited antibacterial activity, with the highest inhibition (up to 97.6%) observed against S. aureus at 500 μg mL⁻¹ of FAkBe. A significant concentration-dependent inhibitory effect was detected.

Limitations on study/implications: However, further studies are required to elucidate the molecular mechanisms involved and to evaluate in vivo efficacy. Findings/conclusions: These findings suggest that polysaccharides from wild edible mushrooms represent a promising source of bioactive compounds with antibacterial potential.