Antivenom properties of Pentalinon sp. (Apocynaceae) against the venom of Bothrops asper

Resumen

Objective: To evaluate the antivenin activity of organic extracts obtained from roots, stems and leaves of Pentalinon sp.

Design/methodology/approach: The phytochemical profile of the extracts was determined, and their inhibitory capacity was assessed against several effects induced by Bothrops asper venom, including lethality, proteolytic activity on azocasein, phospholipase A₂ activity, and fibrinogenolytic activity.

Results: The extracts of Pentalinon sp. predominantly contained flavonoids and terpenoids. None of the tested extracts were able to neutralize the venom’s lethality. However, the ethanolic leaf extract completely inhibited proteolytic activity on azocasein and partially reduced phospholipase A₂ activity.

Findings/conclusions: Root extracts partially inhibited proteolytic activity on azocasein and prevented the degradation of the alpha and beta chains of fibrinogen.